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| Robertapet |
Дата: Пятница, 28.02.2014, 04:08 | Сообщение # 961 |
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Группа: ГоСтИ
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| Triciarini |
Дата: Пятница, 28.02.2014, 07:41 | Сообщение # 962 |
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Группа: ГоСтИ
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А ваши? советуйте что искать |
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| Marfushann |
Дата: Пятница, 28.02.2014, 10:18 | Сообщение # 963 |
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Группа: ГоСтИ
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| Sabinast |
Дата: Пятница, 28.02.2014, 14:58 | Сообщение # 964 |
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Группа: ГоСтИ
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| Carlosfata |
Дата: Пятница, 28.02.2014, 17:09 | Сообщение # 965 |
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Группа: ГоСтИ
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| DanielCalo |
Дата: Пятница, 07.03.2014, 23:13 | Сообщение # 966 |
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Группа: ГоСтИ
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| tcsgroupz |
Дата: Воскресенье, 23.03.2014, 05:46 | Сообщение # 967 |
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Группа: ГоСтИ
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Vancomycin INN /v??k??ma?s?n/ is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused next to Gram-positive bacteria. Vancomycin was first isolated in 1953 at Eli Lilly, from a soil sample collected from the interior jungles of Borneo beside a missionary. It is a inherently occurring antibiotic made past the soil bacterium Actinobacteria species Amycolatopsis orientalis(once upon a time designated Nocardia orientalis). It is a complex chemical mix and an archetype of a comparatively rare haloorganic above increase, containing two covalently bonded chlorine atoms.
The compound was industrially produced alongside fermentation and accepted the generic name vancomycin, derived from the term "vanquish." The master reading payment vancomycin was in behalf of the treatment ofpenicillin-resistant Staphylococcus aureus, a avail oneself of kept astir in behalf of many years beside the fact that compound had to be given intravenously and thus provided bacteria fewer opportunities to evolve intransigence, and the fact that organisms were somewhat boeotian to evolve to reshape to it, coextensive with in experiments.
As regards many years since its initial consume, vancomycin had traditionally been reserved as a drug of "mould repair to" apposite to premature observations of its nephrotoxicity and ototoxicity as well as its intravenous dosing requirements.[1 - Recently, to whatever manner, vancomycin intractable organisms are attractive common. So, vancomycin is increasingly being displaced from this responsibility on newer antibiotics such as linezolid(Zyvox), daptomycin (Cubicin), and quinupristin/dalfopristin (Synercid).
History
Vancomycin was sooner individual in 1953 not later than Edmund Kornfeld (working at Eli Lilly) from a soil sample at ease from the private jungles of Borneo away a missionary.[2 - The being that produced it was in the final analysis named Amycolatopsis orientalis.[3 - The aboriginal clue by reason of vancomycin was in the interest the treatment of penicillin-resistant Staphylococcus aureus.[3 - [4 -
The multiply was initially called concoct 05865, but was in the final analysis given the generic namevancomycin, derived from the length of time "vanquish".[3 - An individual benefit that was instantly apparent is that staphylococci did not emerge critical resistance consideration serial verse in enlightenment media containing vancomycin. The sudden happening of penicillin recalcitrance nearby staphylococci led to the compound's being fast-tracked payment agreement about the Rations and Narcotic Dispensation (FDA) in 1958. Eli Lilly first marketed vancomycin hydrochloride controlled by the trade label Vancocin[4 - and as COVANC from Nucleus, India.[citation needed -
Vancomycin never became the first-line treatment for the treatment of Staphylococcus aureus fitted certain reasons:
1. It possesses insolvent oral bioavailability; it sine qua non be accepted intravenously as a service to most infections.
2. β-Lactamase-resistant semi-synthetic penicillins such as methicillin (and its successors,nafcillin and cloxacillin) were afterward developed, which bear bettor vocation against non-MRSA staphylococci.
3. At cock crow trials cast-off at the crack judaism tref forms of vancomycin ("Mississippi slime"), which were create to be toxic to the ears and to the kidneys;[5 - these findings led to vancomycin's being relegated to the leaning of a anaesthetize of mould resort.[4 -
In 2004, Eli Lilly licensed Vancocin to ViroPharma in the U.S., Flynn Pharma in the UK, and Aspen Pharmacare in Australia. The obvious expired in the primeval 1980s; the FDA authorized the sale of diverse generic versions in the USA, including from manufacturers Bioniche Pharma, Baxter Healthcare, Sandoz, Akorn Strides and Hospira.[6 -
An articulated ceremony of vancomycin was from the outset approved alongside the FDA in 1986 after the treatment of Clostridium difficile induced pseudomembranous colitis. It is not orally buried into the blood and remains in the gastrointestinal essay to eradicate C. difficile. This product is currently marketed nearby ViroPharmain the USA.[7 - |
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| Милена94 |
Дата: Воскресенье, 27.04.2014, 02:49 | Сообщение # 968 |
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Группа: ГоСтИ
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| ThomasRaw |
Дата: Понедельник, 28.04.2014, 17:58 | Сообщение # 969 |
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Группа: ГоСтИ
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| LowellTino |
Дата: Суббота, 17.05.2014, 03:55 | Сообщение # 970 |
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Группа: ГоСтИ
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| marlenekc16 |
Дата: Понедельник, 19.05.2014, 09:45 | Сообщение # 971 |
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Группа: ГоСтИ
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| Ellakem |
Дата: Четверг, 05.06.2014, 13:30 | Сообщение # 972 |
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Группа: ГоСтИ
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| xqnkbwficv |
Дата: Понедельник, 30.06.2014, 16:37 | Сообщение # 973 |
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| RiseMem |
Дата: Суббота, 05.07.2014, 21:23 | Сообщение # 974 |
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Группа: ГоСтИ
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| RiseMem |
Дата: Суббота, 05.07.2014, 21:23 | Сообщение # 975 |
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Группа: ГоСтИ
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